Session Chair: Barry Hardy, Douglas Connect
Monday, 09 February 2015, from 09:00 to 12:00
SUMMARY
This session will discuss the application of computational chemistry, drug design, virtual and experimental screening techniques to the design of inhibitors against malarial targets.
Obligate intracellular parasites from the genus Plasmodium are the agents responsible for malaria, placing an estimated 3.4 billion people at risk of the disease throughout the world.
Scientists Against Malaria (SAM) was formed with the goal of designing novel antimalarial drug candidates.
Scoring molecules by similarity in fundamental 3D properties such as shape, chemical features and electrostatic potential has been a very productive method for hit discovery and lead hopping.
Plasmodium parasites boast a kinome with over 90 members, close to half of which are essential and therefore potential drug targets. They are also all S/T kinases...
