Paul E. Blower, Jr.
Biographical Sketch
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Paul Blower is Chief Scientific Officer at LeadScope, Inc., Columbus, OH and Adjunct Professor, College of Pharmacy, Ohio State University. He received a Ph.D. in organic chemistry from the University of Wisconsin (Madison) in 1975. Prior to joining Leadscope, he worked as a Senior Research Scientist at Chemical Abstracts Service. His expertise is in chemoinformatics and decision support tools for drug discovery. He responsibilities at LeadScope include exploring new applications of chemoinformatics techniques, new chemical content, and research needed to support extensions into allied disciplines such as ADME, toxicology and genomics.
Selected Publications And Conference Presentations (2002-3)

Cross, K.P.; Myatt, G.; Yang, C.; Fligner, M.F.;Verducci, J.S.; Blower, Jr., P.E. Finding Discriminating Structural Features by Reassembling Common Building Blocks, J. Med. Chem., in press.

Blower, P.; Cross, K.; Fligner, M.; Myatt, G.; Verducci, J.; and Yang, C. Systematic analysis of large screening sets, 226th American Chemical Society National Meeting; New York, NY, Sept. 2003.

Blower, P.; Fligner, M.; Verducci, J.; and Yang, C. Informatics Methods for Correlating Molecular Structure with Genomic Data, CHI Beyond Genome Conference, San Diego, CA, June, 2003.

Blower, P.; Fligner, M.; Verducci, J.; and Cross, K. Optimally Balanced Spread Designs for Compound Selection, CHI Intelligent Drug Discovery and Development Conference, Philadelphia, PA, May, 2003.

P. Blower, J. Whetstone; Structural analysis of Leadscope’s Known Drugs database, 225th American Chemical Society National Meeting; New Orleans, LA, Apr. 2003.

Blower, P. E. Jr.; Yang, C; Fligner, M. A.; Verducci, J. S.; Yu, L.; Richman, S.; Weinstein, J. N. Pharmacogenomic Analysis: Correlating Molecular Substructure Classes with Microarray Gene Expression Data, Pharmacogen. J. 2002, 2, 259–271.

Fligner, M. A.; Verducci, J. S.; Blower, P. E. Jr. A Modification of the Jaccard/Tanimoto Similarity Index for Diverse Selection of Chemical Compounds Using Binary Strings, Technometrics, 2002, 1-10.

P. Blower, M. Fligner, J. Verducci, and J. Bjoraker; On Combining Recursive Partitioning and Simulated Annealing To Detect Groups of Biologically Active Compounds, J. Chem. Inf.Comput. Sci., 2002, 42, 393-404.

P. Blower; Building QSAR Models From Large Screening Sets, Society for Biomolecular Screening, 8th Annual Conference, The Hague, The Netherlands, Sept. 22-6, 2002.