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- Biggin, P
- Bolger, M
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- Gata-Aura, J
- Goodman, J
- Hardy, B
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Dr. Ulrike Uhrig studied Pharmacy at the Freie Universität Berlin, Germany. Shortly after joining the research group of Professor H.-D. Höltje the whole group moved to Heinrich-Heine Universität Düsseldorf, Germany. During her Ph.D. she focused mainly on Ligand-based Design methods but also got in touch with Structure-based methods. After finishing her Ph.D. she joined Tripos in 1999 as a Support Scientist. Here she entered into the broad range of technologies in an expert molecular modeling environment, including Ligand- and Structure-based Design methods, Cheminformatics, Library Design and more. After two years she became an Application Scientist and started to do training for customers. Today she is managing Tripos Application Scientists in Europe and is in charge of training sessions offered by Tripos in Europe.
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| Workshop, 13 September 2007, Chemistry Research Laboratory, Oxford University |
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Advanced Protein Modeling
Workshop Instructor: Ulrike Uhrig, Tripos
This workshop focuses on building 3D protein models from sequences using the powerful tools included in SYBYL’s® Advanced Protein Modeling module (based on the FUGUE™ and ORCHESTRAR™ technologies).
This method builds on traditional homology modeling by including structural comparison into sequence alignment. Participants will search a database to find proteins that are homologous to a target sequence and use these homologous proteins as templates to construct a protein model of the target sequence. Attendees will determine the binding site in this model through the use of molecular surfaces and by comparing the model to other protein structures. By attending this workshop, participants will gain a knowledge of how to
•Create a 3D protein structure from your sequence for use in further molecular modeling studies.
•Derive reliable models from a high-quality, expansive database of protein structures.
•Detect distant homologs of your target sequence.
•Produce superior alignments based on structure and sequence information.
Participants will also take home: A free 30-day license of SYBYL(r), Biopolymer(tm), and Advanced Protein Modeling for Linux and IRIX operating systems.
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