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| Dmitrii Rassokhin, Johnson & Johnson PR&D, LLC |
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| Dmitrii N. Rassokhin received his M.S. in 1988 and Ph.D. in physical chemistry in 1996 from M.V. Lomonosov Moscow State University (MSU), Russia. Until 1998, Dr. Rassokhin worked in the areas of sonochemistry and radiation chemistry of aqueous solutions in the Laboratory of Radiation Chemistry at MSU. His second field of interest, computational chemistry and modern programming techniques, emerged when Dr. Rassokhin developed software for the modeling of pulse radiolysis kinetics. In 1998, Dr. Rassokhin joined 3-Dimensional Pharmaceuticals, Inc. Following the acquisition of 3DP by Johnson & Johnson, he has assumed the position of Principal Research Scientist in the Molecular Design and Informatics group. He is actively involved in the development of the computational methods and software supporting compound and screening logistics.
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High-performance Applications Based on Web Services: It's Not an Oxymoron. The Use of Web Services in the ABCD Drug Discovery Platform.
Dmitrii N. Rassokhin, Johnson & Johnson PR & D, LLC
A Web service is a software system designed to support interoperable machine-to-machine interaction over a network. The interaction is accomplished by exchanging specially formatted messages over the HTTP protocol according to a set of Web-related standards. Distributed applications based on web services have several compelling advantages over those based on RMI, CORBA, or DCOM, such as the ease of component reuse and integration into larger distributed systems and the ability to work through most common firewalls. However, since web services use very sparse and redundant XML-formatted messages to exchange data, data transfer can dramatically decrease the performance of web service-based systems. Therefore, the key to achieving high performance in such systems is performing computationally intensive tasks on the server, while minimizing and optimizing the client-server data exchange as much as possible.
This presentation will discuss the design and architecture of two such high-performance web services designed for substructure and similarity searching of large compound libraries. Both services were developed by the MDI team at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. as a part of the ABCD drug discovery platform.
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