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| Adel Golovin, European Bioinformatics Institute |
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In 1991, along with full time education at Moscow Technology University, Adel Golovin started working as a Software Developer.
In 1994 he graduated from Moscow Technology University with a Degree in Software Development for Computer Aided Engineering and Design.
In 1996 he started development of database applications for such industries as telecommunications, stock market, and publishing.
He has been working at EBI since 2001 where his major achievement has been the development of the MSDsite database, search engine and an interface for Active Sites search and visualization.
He has published about 10 articles on and presented MSDservices throughout the EU.
His primary current interests are algorithms and visualization for drug descovery.
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MSDmotif: A Database Search and Retrieval System for the Analysis and Viewing of Protein Structure Motifs
Adel Golovin, EMBL Outstation, The European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
A variety of small three-dimensional hydrogen-bonded motifs occur in proteins with well-known examples including the beta turn. For the structures in the Protein Data Bank (PDB) the data for defined small motifs has been derived and loaded into a relational database. The main motifs follow the definitions from James Milner-White. The motif database allows users to mine this data in the context of the whole protein three-dimension structure and in relationship to sequence and active site binding sites together with prosite patterns. MSDmotif is also part of the MSD database where the entry unit is the likely biological assembly of the quaternary structure. A fast interactive search and retrieval system has been developed. Prosite pattern and sequence search options are available together with a graphical query generator. Complete statistics are available for the 11 most common motifs and query results are made available in a 3D alignment. The database is incremented weekly and the query system is available as a web application server with J2EE servlet engine. The database and its query interface are accessible from the Internet through a web
server located at: http://www.ebi.ac.uk/msd-srv/msdmotif
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